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首頁(yè) > 抗體 > 一抗 > 其它 > Elk1 Monoclonal Antibody
Elk1 Monoclonal Antibody
商品貨號(hào): PLA004767
適 應(yīng) 性:
WB IHC IF ELISA
¥600元
規(guī)格:
在線咨詢
MSDS
說明書
商品描述
  • 發(fā)貨日期: 7
  • 基因名稱: ELK1
  • 蛋白名稱: ETS domain-containing protein Elk-1
  • Human_gene_id: 2002
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2002
  • Human_swiss_prot_no: P19419
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P19419/entry
  • Mouse_swiss_prot_no: P41969
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P41969
  • 特異性: Elk1 Monoclonal Antibody detects endogenous levels of Elk1 protein.
  • 組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源: Monoclonal, Mouse
  • 稀釋: WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝: Affinity purification
  • 儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名稱: ELK1; ETS domain-containing protein Elk-1
  • 信號(hào)通路: MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Focal adhesion;Insulin_Receptor;GnRH;Prion diseases;Endometrial cancer;
  • 功能: function:Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.,PTM:On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity.,PTM:Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,subunit:Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity.,tissue specificity:Lung and testis.,
  • 相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位: Nucleus.
  • 組織表達(dá): Lung and testis.
  • 科研貨號(hào): PLA004767
Elk1 Monoclonal Antibody
Catalog No PLA004767
Product information
  • 發(fā)貨日期: 7
  • 基因名稱: ELK1
  • 蛋白名稱: ETS domain-containing protein Elk-1
  • Human_gene_id: 2002
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2002
  • Human_swiss_prot_no: P19419
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P19419/entry
  • Mouse_swiss_prot_no: P41969
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P41969
  • 特異性: Elk1 Monoclonal Antibody detects endogenous levels of Elk1 protein.
  • 組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源: Monoclonal, Mouse
  • 稀釋: WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝: Affinity purification
  • 儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名稱: ELK1; ETS domain-containing protein Elk-1
  • 信號(hào)通路: MAPK_ERK_Growth;MAPK_G_Protein;ErbB_HER;Focal adhesion;Insulin_Receptor;GnRH;Prion diseases;Endometrial cancer;
  • 功能: function:Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.,PTM:On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-383 and Ser-389 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity.,PTM:Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.,similarity:Belongs to the ETS family.,similarity:Contains 1 ETS DNA-binding domain.,subunit:Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity.,tissue specificity:Lung and testis.,
  • 相關(guān)產(chǎn)品: RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位: Nucleus.
  • 組織表達(dá): Lung and testis.
  • 科研貨號(hào): PLA004767
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.jx3dscan.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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