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首頁 > 抗體 > 一抗 > 其它 > Fibulin-5 Monoclonal Antibody
Fibulin-5 Monoclonal Antibody
商品貨號： PLA004807
適 應(yīng) 性： 人
WB IHC IF ELISA
￥600元
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： FBLN5
  • 蛋白名稱： Fibulin-5
  • Human_gene_id： 10516
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10516
  • Human_swiss_prot_no： Q9UBX5
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9UBX5/entry
  • Mouse_swiss_prot_no： Q9WVH9
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WVH9
  • 特異性： Fibulin-5 Monoclonal Antibody detects endogenous levels of Fibulin-5 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： FBLN5; DANCE; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
  • 功能： disease:Defects in FBLN5 are a cause of autosomal dominant cutis laxa [MIM:123700]. Hereditary cutis laxa refers to a heterogeneous group of connective tissue disorders characterized by cutaneous abnormalities and variable systemic manifestations. The most constant clinical feature is loose skin, sagging over the face and trunk. Hereditary cutis laxa is inherited in both autosomal dominant and autosomal recessive modes. Autosomal dominant cutis laxa is a relatively benign inherited and acquired connective tissue disorder.,disease:Defects in FBLN5 are a cause of autosomal recessive cutis laxa type I (CL type I) [MIM:219100]. CL type I shows the most severe phenotype and has the poorest prognosis. In addition to the skin, internal organs enriched in elastic fibers, such as the lung and arteries, are affected.,disease:Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3) [MIM:608895]. ARMD is a multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.,function:Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.,similarity:Belongs to the fibulin family.,similarity:Contains 6 EGF-like domains.,tissue specificity:Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Secreted . Secreted, extracellular space, extracellular matrix . co-localizes with ELN in elastic fibers. .
  • 組織表達： Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
  • 科研貨號： PLA004807
Fibulin-5 Monoclonal Antibody
Catalog No PLA004807
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： FBLN5
  • 蛋白名稱： Fibulin-5
  • Human_gene_id： 10516
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10516
  • Human_swiss_prot_no： Q9UBX5
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q9UBX5/entry
  • Mouse_swiss_prot_no： Q9WVH9
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9WVH9
  • 特異性： Fibulin-5 Monoclonal Antibody detects endogenous levels of Fibulin-5 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： FBLN5; DANCE; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
  • 功能： disease:Defects in FBLN5 are a cause of autosomal dominant cutis laxa [MIM:123700]. Hereditary cutis laxa refers to a heterogeneous group of connective tissue disorders characterized by cutaneous abnormalities and variable systemic manifestations. The most constant clinical feature is loose skin, sagging over the face and trunk. Hereditary cutis laxa is inherited in both autosomal dominant and autosomal recessive modes. Autosomal dominant cutis laxa is a relatively benign inherited and acquired connective tissue disorder.,disease:Defects in FBLN5 are a cause of autosomal recessive cutis laxa type I (CL type I) [MIM:219100]. CL type I shows the most severe phenotype and has the poorest prognosis. In addition to the skin, internal organs enriched in elastic fibers, such as the lung and arteries, are affected.,disease:Defects in FBLN5 are the cause of age-related macular degeneration type 3 (ARMD3) [MIM:608895]. ARMD is a multifactorial disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid (known as drusen) that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.,function:Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling.,similarity:Belongs to the fibulin family.,similarity:Contains 6 EGF-like domains.,tissue specificity:Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Secreted . Secreted, extracellular space, extracellular matrix . co-localizes with ELN in elastic fibers. .
  • 組織表達： Expressed in skin fibroblasts (at protein level)(PubMed:17035250). Expressed predominantly in heart, ovary, and colon but also in kidney, pancreas, testis, lung and placenta. Not detectable in brain, liver, thymus, prostate, or peripheral blood leukocytes (PubMed:10428823).
  • 科研貨號： PLA004807
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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