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HFE Monoclonal Antibody
商品貨號(hào)： PLA004848
適 應(yīng) 性： 人
WB IF ELISA
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： HFE
  • 蛋白名稱： Hereditary hemochromatosis protein
  • Human_gene_id： 3077
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3077
  • Human_swiss_prot_no： Q30201
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q30201/entry
  • Mouse_swiss_prot_no： P70387
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P70387
  • 特異性： HFE Monoclonal Antibody detects endogenous levels of HFE protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： HFE; HLAH; Hereditary hemochromatosis protein; HLA-H
  • 功能： alternative products:Additional isoforms seem to exist,disease:Defects in HFE are a cause of hereditary hemochromatosis (HH) [MIM:235200]. HH is an autosomal recessive inborn disorder of iron metabolism. It is the most common recessive disease in Caucasians. HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects.,disease:Defects in HFE are a cause of porphyria variegata (PV) [MIM:176200]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. PV is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease.,disease:Defects in HFE are associated with susceptibility to diabetic nephropathy [MIM:612635]; also called susceptibility to microvascular complications of diabetes type 7 (MVCD7) or susceptibility to diabetic proliferative retinopathy. Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.,similarity:Belongs to the MHC class I family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Binds TFR through the extracellular domain in a pH-dependent manner.,tissue specificity:In all tissues tested except brain.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Cell membrane ; Single-pass type I membrane protein .
  • 組織表達(dá)： Expressed in all tissues tested except brain.
  • 科研貨號(hào)： PLA004848
HFE Monoclonal Antibody
Catalog No PLA004848
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： HFE
  • 蛋白名稱： Hereditary hemochromatosis protein
  • Human_gene_id： 3077
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3077
  • Human_swiss_prot_no： Q30201
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q30201/entry
  • Mouse_swiss_prot_no： P70387
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P70387
  • 特異性： HFE Monoclonal Antibody detects endogenous levels of HFE protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： HFE; HLAH; Hereditary hemochromatosis protein; HLA-H
  • 功能： alternative products:Additional isoforms seem to exist,disease:Defects in HFE are a cause of hereditary hemochromatosis (HH) [MIM:235200]. HH is an autosomal recessive inborn disorder of iron metabolism. It is the most common recessive disease in Caucasians. HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects.,disease:Defects in HFE are a cause of porphyria variegata (PV) [MIM:176200]. Porphyrias are inherited defects in the biosynthesis of heme, resulting in the accumulation and increased excretion of porphyrins or porphyrin precursors. They are classified as erythropoietic or hepatic, depending on whether the enzyme deficiency occurs in red blood cells or in the liver. PV is the most common form of porphyria in South Africa. It is characterized by skin hyperpigmentation and hypertrichosis, abdominal pain, tachycardia, hypertension and neuromuscular disturbances. High fecal levels of protoporphyrin and coproporphyrin, increased urine uroporphyrins and iron overload are typical markers of the disease.,disease:Defects in HFE are associated with susceptibility to diabetic nephropathy [MIM:612635]; also called susceptibility to microvascular complications of diabetes type 7 (MVCD7) or susceptibility to diabetic proliferative retinopathy. Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.,similarity:Belongs to the MHC class I family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Binds TFR through the extracellular domain in a pH-dependent manner.,tissue specificity:In all tissues tested except brain.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Cell membrane ; Single-pass type I membrane protein .
  • 組織表達(dá)： Expressed in all tissues tested except brain.
  • 科研貨號(hào)： PLA004848
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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