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首頁 > 抗體 > 一抗 > 其它 > IRAK-4 Monoclonal Antibody
IRAK-4 Monoclonal Antibody
商品貨號(hào)： PLA004883
適 應(yīng) 性： 人,小鼠,猴
WB IHC IF ELISA FCM
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： IRAK4
  • 蛋白名稱： Interleukin-1 receptor-associated kinase 4
  • Human_gene_id： 51135
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51135
  • Human_swiss_prot_no： Q8TDF7
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8TDF7/entry
  • 特異性： IRAK-4 Monoclonal Antibody detects endogenous levels of IRAK-4 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 信號(hào)通路： Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Toll_Like;Neurotrophin;
  • 功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.,disease:Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.,function:Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.,online information:IRAK4 mutation db,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： extracellular space,intracellular,nucleus,cytoplasm,cytosol,plasma membrane,endosome membrane,
  • 組織表達(dá)： Brain,Spleen,Uterus,
  • 科研貨號(hào)： PLA004883
IRAK-4 Monoclonal Antibody
Catalog No PLA004883
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： IRAK4
  • 蛋白名稱： Interleukin-1 receptor-associated kinase 4
  • Human_gene_id： 51135
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51135
  • Human_swiss_prot_no： Q8TDF7
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8TDF7/entry
  • 特異性： IRAK-4 Monoclonal Antibody detects endogenous levels of IRAK-4 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 信號(hào)通路： Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Toll_Like;Neurotrophin;
  • 功能： catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.,disease:Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD.,function:Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.,online information:IRAK4 mutation db,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.,similarity:Contains 1 death domain.,similarity:Contains 1 protein kinase domain.,subunit:IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： extracellular space,intracellular,nucleus,cytoplasm,cytosol,plasma membrane,endosome membrane,
  • 組織表達(dá)： Brain,Spleen,Uterus,
  • 科研貨號(hào)： PLA004883
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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