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首頁 > 抗體 > 一抗 > 其它 > N-CoR Monoclonal Antibody
N-CoR Monoclonal Antibody
商品貨號： PLA004952
適 應(yīng) 性： 人
WB IHC IF ELISA
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： NCOR1
  • 蛋白名稱： Nuclear receptor corepressor 1
  • Human_gene_id： 9611
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9611
  • Human_swiss_prot_no： O75376
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O75376/entry
  • Mouse_swiss_prot_no： Q60974
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60974
  • 特異性： N-CoR Monoclonal Antibody detects endogenous levels of N-CoR protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： NCOR1; KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1
  • 功能： domain:The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.,domain:The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).,function:Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.,PTM:Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the N-CoR nuclear receptor corepressors family.,similarity:Contains 2 SANT domains.,subunit:Interacts with SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and MJD2A/JHDM3A. Interacts with ZBTB33/KAISO, and this interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with the catalytic domain of HDAC9. Interacts with CBFA2T3 and HEXIM1. Interacts with C1D.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus .
  • 組織表達(dá)： Brain,Colon,Epithelium,Fetal brain,Lung,Ovary,Pancreas,Pooled,Skin,Testis,
  • 科研貨號： PLA004952
N-CoR Monoclonal Antibody
Catalog No PLA004952
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： NCOR1
  • 蛋白名稱： Nuclear receptor corepressor 1
  • Human_gene_id： 9611
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9611
  • Human_swiss_prot_no： O75376
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/O75376/entry
  • Mouse_swiss_prot_no： Q60974
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q60974
  • 特異性： N-CoR Monoclonal Antibody detects endogenous levels of N-CoR protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： NCOR1; KIAA1047; Nuclear receptor corepressor 1; N-CoR; N-CoR1
  • 功能： domain:The C-terminal region contains two separate nuclear receptor-interacting domains (ID1 and ID2), each of which contains a conserved sequence referred to as the CORNR box. This motif is necessary and sufficient for binding to unligated nuclear hormone receptors, while sequences flanking the CORNR box determine the precise nuclear hormone receptor specificity.,domain:The N-terminal region contains three independent domains that are capable of mediating transcriptional repression (RD1, RD2 and RD3).,function:Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.,PTM:Ubiquitinated; mediated by SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the N-CoR nuclear receptor corepressors family.,similarity:Contains 2 SANT domains.,subunit:Interacts with SIAH2, HDAC7, SAP30, SIN3A and SIN3B (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand. Interacts with DACH1. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Interacts with TRIM28 and MJD2A/JHDM3A. Interacts with ZBTB33/KAISO, and this interaction serves to recruit the N-CoR complex to promoter regions containing methylated CpG dinucleotides. Interacts with the catalytic domain of HDAC9. Interacts with CBFA2T3 and HEXIM1. Interacts with C1D.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus .
  • 組織表達(dá)： Brain,Colon,Epithelium,Fetal brain,Lung,Ovary,Pancreas,Pooled,Skin,Testis,
  • 科研貨號： PLA004952
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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