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首頁(yè) > 抗體 > 一抗 > 其它 > PARP-1 Monoclonal Antibody
PARP-1 Monoclonal Antibody
商品貨號(hào): PLA004978
適 應(yīng) 性:
WB ELISA FCM
¥600元
規(guī)格:
在線咨詢
MSDS
說明書
商品描述
  • 發(fā)貨日期: 7
  • 基因名稱: PARP1
  • 蛋白名稱: Poly [ADP-ribose] polymerase 1
  • Human_gene_id: 142
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=142
  • Human_swiss_prot_no: P09874
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P09874/entry
  • Mouse_swiss_prot_no: P11103
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P11103
  • 特異性: PARP-1 Monoclonal Antibody detects endogenous levels of PARP-1 protein.
  • 組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源: Monoclonal, Mouse
  • 稀釋: WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝: Affinity purification
  • 儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名稱: PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1
  • 信號(hào)通路: Base excision repair;
  • 功能: catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.,miscellaneous:The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.,PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Poly-ADP-ribosylated by PARP2.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 2 PARP-type zinc fingers.,subunit:Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423.,
  • 相關(guān)產(chǎn)品: YT5695,YM3145,YM3132,YM3131,YK0091,YC0101,YC0073,KA3972C,KA3971C
  • 細(xì)胞定位: Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
  • 組織表達(dá): Brain,Colon carcinoma,Fibroblast,Lung,Ovarian carcinoma,Skin,
  • 科研貨號(hào): PLA004978
PARP-1 Monoclonal Antibody
Catalog No PLA004978
Product information
  • 發(fā)貨日期: 7
  • 基因名稱: PARP1
  • 蛋白名稱: Poly [ADP-ribose] polymerase 1
  • Human_gene_id: 142
  • Human_gene_link: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=142
  • Human_swiss_prot_no: P09874
  • Human_swiss_link: http://www.uniprot.org/uniprotkb/P09874/entry
  • Mouse_swiss_prot_no: P11103
  • Mouse_swiss_link: http://www.uniprot.org/uniprot/P11103
  • 特異性: PARP-1 Monoclonal Antibody detects endogenous levels of PARP-1 protein.
  • 組成: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源: Monoclonal, Mouse
  • 稀釋: WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝: Affinity purification
  • 儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書: 1
  • Msds: MSDS_Antibody.pdf
  • 其他名稱: PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1
  • 信號(hào)通路: Base excision repair;
  • 功能: catalytic activity:NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.,function:Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.,miscellaneous:The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.,PTM:Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Poly-ADP-ribosylated by PARP2.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 PARP alpha-helical domain.,similarity:Contains 1 PARP catalytic domain.,similarity:Contains 2 PARP-type zinc fingers.,subunit:Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423.,
  • 相關(guān)產(chǎn)品: YT5695,YM3145,YM3132,YM3131,YK0091,YC0101,YC0073,KA3972C,KA3971C
  • 細(xì)胞定位: Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
  • 組織表達(dá): Brain,Colon carcinoma,Fibroblast,Lung,Ovarian carcinoma,Skin,
  • 科研貨號(hào): PLA004978
  • Hunan UPT Biotechnology Co.,Ltd
    Website:www.jx3dscan.com Servive hotline :4006916686
    E-mail:service@uptbio.com
    Address:
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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