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首頁 > 抗體 > 一抗 > 其它 > PYK2 Monoclonal Antibody
PYK2 Monoclonal Antibody
商品貨號： PLA005005
適 應 性： 人
WB IHC IF ELISA
￥600元
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： PTK2B
  • 蛋白名稱： Protein-tyrosine kinase 2-beta
  • Human_gene_id： 2185
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2185
  • Human_swiss_prot_no： Q14289
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q14289/entry
  • Mouse_swiss_prot_no： Q9QVP9
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QVP9
  • 特異性： PYK2 Monoclonal Antibody detects endogenous levels of PYK2 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro
  • 信號通路： Calcium;Chemokine;Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;GnRH;
  • 功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.,PTM:Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by PKC activation. Recruitment by nephrocystin to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Interaction with nephrocystin induces the membrane-association of the kinase.,subunit:Interacts with Crk-associated substrate (Cas), PTPNS1 and SH2D3C (By similarity). Interacts with nephrocystin, ASAP2, OPHN1L, SKAP2 and TGFB1I1.,tissue specificity:Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney. Also expressed in spleen and lymphocytes.,
  • 相關(guān)產(chǎn)品： YT3915,YT3914,YT3913,YT3912,YP1122,YP0810,YP0610,YP0609,KA4258C,KA1736C,KA1218C,KA1217C
  • 細胞定位： Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery.
  • 組織表達： Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney (at protein level). Also expressed in spleen and lymphocytes.
  • 科研貨號： PLA005005
PYK2 Monoclonal Antibody
Catalog No PLA005005
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： PTK2B
  • 蛋白名稱： Protein-tyrosine kinase 2-beta
  • Human_gene_id： 2185
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2185
  • Human_swiss_prot_no： Q14289
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q14289/entry
  • Mouse_swiss_prot_no： Q9QVP9
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q9QVP9
  • 特異性： PYK2 Monoclonal Antibody detects endogenous levels of PYK2 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
  • 純化工藝： Affinity purification
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PTK2B; FAK2; PYK2; RAFTK; Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Pro
  • 信號通路： Calcium;Chemokine;Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;GnRH;
  • 功能： catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.,PTM:Phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by PKC activation. Recruitment by nephrocystin to cell matrix adhesions initiates Tyr-402 phosphorylation. In monocytes, adherence to substrata is required for tyrosine phosphorylation and kinase activation. Angiotensin II, thapsigargin and L-alpha-lysophosphatidic acid (LPA) also induce autophosphorylation and increase kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Interaction with nephrocystin induces the membrane-association of the kinase.,subunit:Interacts with Crk-associated substrate (Cas), PTPNS1 and SH2D3C (By similarity). Interacts with nephrocystin, ASAP2, OPHN1L, SKAP2 and TGFB1I1.,tissue specificity:Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney. Also expressed in spleen and lymphocytes.,
  • 相關(guān)產(chǎn)品： YT3915,YT3914,YT3913,YT3912,YP1122,YP0810,YP0610,YP0609,KA4258C,KA1736C,KA1218C,KA1217C
  • 細胞定位： Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, focal adhesion. Cell projection, lamellipodium. Cytoplasm, cell cortex. Nucleus. Interaction with NPHP1 induces the membrane-association of the kinase. Colocalizes with integrins at the cell periphery.
  • 組織表達： Most abundant in the brain, with highest levels in amygdala and hippocampus. Low levels in kidney (at protein level). Also expressed in spleen and lymphocytes.
  • 科研貨號： PLA005005
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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