av成年人在线观看-中文字幕av每日更新人妻-日韩欧美国产中文综合-日本国产久久久久-超碰天天夜夜网-日韩男女啪啪图-久久精品视频这里有精品-中文字幕在线一区av-亚洲天堂激情啪啪网,中文字幕午夜av福利,久久99九九婷婷精品综合,国产高潮国产高潮久久

首頁(yè) > 抗體 > 一抗 > 其它 > RUNX1 Monoclonal Antibody
RUNX1 Monoclonal Antibody
商品貨號(hào)： PLA005026
適 應(yīng) 性： 人
WB IF ELISA
￥600元
規(guī)格：
在線咨詢
MSDS
說(shuō)明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： RUNX1
  • 蛋白名稱： Runt-related transcription factor 1
  • Human_gene_id： 861
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=861
  • Human_swiss_prot_no： Q01196
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q01196/entry
  • Mouse_swiss_prot_no： Q03347
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q03347
  • 特異性： RUNX1 Monoclonal Antibody detects endogenous levels of RUNX1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： RUNX1; AML1; CBFA2; Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha
  • 信號(hào)通路： Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;
  • 功能： alternative products:Additional isoforms seem to exist,caution:The fusion of AML1 with EAP in T-MDS induces a change of reading frame in the latter resulting in 17 AA unrelated to those of EAP.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with EAP, MSD1 or EVI1.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelomonocytic leukemia. Inversion inv(21)(q21;q22) with USP16.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of M2 type acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1T1/MTG8/ETO.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of therapy-related myelodysplastic syndrome (T-MDS). Translocation t(3;21)(q26;q22) with EAP, MSD1 or EVI1.,disease:A chromosomal aberration involving RUNX1/AML1 is found in childhood acute lymphoblastic leukemia (ALL). Translocation t(12;21)(p13;q22) with TEL. The translocation fuses the 3'-end of TEL to the alternate 5'-exon of AML-1H.,disease:A chromosomal aberration involving RUNX1/AML1 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.,disease:Defects in RUNX1 are the cause of familial platelet disorder with associated myeloid malignancy (FPDMM) [MIM:601399]. FPDMM is an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.,domain:A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.,function:CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.,PTM:Methylated.,PTM:Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with MYST3.,similarity:Contains 1 Runt domain.,subunit:Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with MYST3 and MYST4. Interacts with SUV39H1, leading to abrogate the transactivating and DNA-binding properties of RUNX1.,tissue specificity:Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.,
  • 相關(guān)產(chǎn)品： YT4191,YT4190,YT4189,YP0622,YP0459,YP0293,KA3994C,KA1740C,KA1235C,KA1234C
  • 細(xì)胞定位： Nucleus.
  • 組織表達(dá)： Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
  • tag： hot
  • 科研貨號(hào)： PLA005026
RUNX1 Monoclonal Antibody
Catalog No PLA005026
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： RUNX1
  • 蛋白名稱： Runt-related transcription factor 1
  • Human_gene_id： 861
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=861
  • Human_swiss_prot_no： Q01196
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/Q01196/entry
  • Mouse_swiss_prot_no： Q03347
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q03347
  • 特異性： RUNX1 Monoclonal Antibody detects endogenous levels of RUNX1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： RUNX1; AML1; CBFA2; Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha
  • 信號(hào)通路： Pathways in cancer;Chronic myeloid leukemia;Acute myeloid leukemia;
  • 功能： alternative products:Additional isoforms seem to exist,caution:The fusion of AML1 with EAP in T-MDS induces a change of reading frame in the latter resulting in 17 AA unrelated to those of EAP.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with EAP, MSD1 or EVI1.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelomonocytic leukemia. Inversion inv(21)(q21;q22) with USP16.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of M2 type acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1T1/MTG8/ETO.,disease:A chromosomal aberration involving RUNX1/AML1 is a cause of therapy-related myelodysplastic syndrome (T-MDS). Translocation t(3;21)(q26;q22) with EAP, MSD1 or EVI1.,disease:A chromosomal aberration involving RUNX1/AML1 is found in childhood acute lymphoblastic leukemia (ALL). Translocation t(12;21)(p13;q22) with TEL. The translocation fuses the 3'-end of TEL to the alternate 5'-exon of AML-1H.,disease:A chromosomal aberration involving RUNX1/AML1 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.,disease:Defects in RUNX1 are the cause of familial platelet disorder with associated myeloid malignancy (FPDMM) [MIM:601399]. FPDMM is an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.,domain:A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.,function:CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4-dependent transcriptional activation.,PTM:Methylated.,PTM:Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with MYST3.,similarity:Contains 1 Runt domain.,subunit:Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with MYST3 and MYST4. Interacts with SUV39H1, leading to abrogate the transactivating and DNA-binding properties of RUNX1.,tissue specificity:Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.,
  • 相關(guān)產(chǎn)品： YT4191,YT4190,YT4189,YP0622,YP0459,YP0293,KA3994C,KA1740C,KA1235C,KA1234C
  • 細(xì)胞定位： Nucleus.
  • 組織表達(dá)： Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.
  • tag： hot
  • 科研貨號(hào)： PLA005026
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
普拉特澤實(shí)驗(yàn)室電話助手

4006916686

掃碼咨詢

人妻x人妻在线观看-亚洲高黄一区二区三区-狠狠狠久久久二区三区-中文字幕av在线日产 | 激情综合激情五月俺也去,-少妇久久久久一区-日本中文字幕资源-国产av大片一区二区三区 | 国产综合久久91大片-热久久成人国际精品-天天舔天天爱天天做-99re久久精品国产热99 | 99热国产精品五月天-97国产精品久久精品国产麻豆-中文字幕人妻熟女网站-91免费看欧洲精品国产nba | 成人av亚洲一区二区-亚洲国产精品欧美日韩在线观看-日本中文字幕熟女人妻在线观看-色婷婷亚洲欧洲图片 | 国产一区二区自拍欧美-久久黑丝少妇小视频-99日精品视频在线观看-一本一道久久综合狠狠操 | 亚洲avav天堂av在线网-亚洲av黄色在线影视-2018天天干天天操天天日-日韩性生活免费观看视频 | 国产一区二区三区极品人妻-久久精品人妻免费观看-91精彩刺激对白露脸偷拍-国产在线观看阿97 | 国产精品久久久久久精品之户外-亚洲456精品视频在线观看-91精品国模一区二区三区-日韩av操bb | 日韩素人中文字幕在线观看-欧美成人av在线一区二区-久久国产36精品色熟妇-欧美日韩色图第一页 | 欧美国精产品一二区-国产美女福利视频一区二区三区-99精品久久精品视频-日韩有码中文字幕一区 | 不卡在线观看一区二区三区-中文字幕麻豆在线观看-自拍视频国内自拍两个熟女-久久久美女16p | 国产亚洲欧洲av在线-国产69精品久久久久777-国产小视频你懂的在线欧美-久久草青青草av | 日韩av中文字幕专区-91精品久久久久久久久久久久久久久-日韩成人在线观看免费观看-日本精品中文字幕66 | 99久久综合狠狠综合久久aⅴ-久久精品亚洲成在人线av网址-精品蜜桃午夜三级一区二区三区-精品久久一久久中文 | 日韩夫妻性生活大片-免费人成黄页在线观看国产-亚洲日本久久久久婷婷-久久99国产蜜臀精品 | 精品视频蜜桃久久久久-日韩美免费观看视频-精品99国产乱码久久久久密-久久久久久亚洲女同第一区暖暖 | 91啪啪啪免费网站-中文字幕视频在线精二-亚洲精品乱码久久久久久久久久久久-国产精品久久久久久久久乱码 | 国精产品乱码一区一区三区四区-99热精品最新网址-91麻豆久久一级中文字幕-亚洲熟妇久久国内精品,亚洲热妇天码av,,,, | 久久综合九色综合久-婷婷九月丁香综合网-678av在线视频-欧美视频一区二区三 | 肥熟女一区二区三肥熟女-午夜精品久久久久久久91-98av一区二区三区-国产精品久久久久久粉嫩av | 久久人妻人人澡人人爽人人精品-久久久国产综合成人精品-99久久久精品久久久久久久-日本美国一区二区不卡伦理 | 午夜国产精品国自产拍av-欧美国产高清在线观看-99精品视频免费观看视频-亚洲成人网在线免费 | 亚洲国产精品人人做人人爽-精品久久久三级-久久亚洲一区二区三区四区五区-日韩精品视频在线观看视频 | 91久久人妻中文字幕-91精品国产综合久久99精品-中文字幕在线中…av-精品女同一区二区三区在线在线 | 中文字幕人妻丝袜乱一区三区-91久久精品人妻在线观看-视频精品一区 二区 三区一-丁香六月天婷婷激情 | 亚洲国产成人久久综合下载-人妻系列中文字幕在线一区-欧美日韩中文字幕视频不卡一二区-国产麻豆成人在线视频 | 日韩中文字幕电影在线观看网址-97caopao视频在线-av中文字幕在-欧美中文字幕在线观看一区 | 性久久久久91麻豆-日本中文字幕久久看-91老熟女对白露脸-久久精品这里是国产电影 | 日韩片黄色在线观看网站-懂色av一区二区三区四区精品-日韩毛片123-国产69精品久久孕妇 | 国产高国产高潮久久久久久-欧美日韩一区二区三区妖精-国产人妻精品中文字幕-久久国产精品久久伊人91 | 国产av受不了了av在线观看-丁香六月婷婷俺也来-av在线观看免费视频网站-蜜桃成人在线观看网址 | 日韩午夜av在线播放-97久久超碰国产精品只有精品-国产日韩激情视频在线-人妻蜜乳1～3中文字幕 | 国产成人精品亚洲日本在线观看-99热在线免费精品-久久久熟妇xxxx网站-精品国产免费久久久久久婷婷 | av在线免费看中文字幕-人妻视频久久久久久久久久-日韩精品一二在线观看-久热这里只有免费精品 | 精品国产91蜜臀内射久久-国产成人小视频在线-99久在线国内在线播放免费观看-蜜桃臀久久久久婷婷免费视频 | 精品人妻中文字幕熟女-在线观看视频综合网九色91-99pao成人国产永久免费视频-lanarhoades高潮喷水 | 日韩黄色免费看片-日韩精品人妻av在线-国产一区二区三区蝌蚪-国产又大又爽又猛 | av一区二区精品久久-日韩欧美伦理片在线播放-国产精品99久久久久久久久久久-久成人免费精品xxx | 91精品少妇一区二区三区蜜桃臀-日韩国产精品欧美92-日韩欧美亚洲综合在线-麻豆av传媒在线免费播放 | 欧美日韩国产另类在线观看-欧美日韩一区二区三区短视频-人妻少妇精品中文字幕av蜜桃-日韩久久久久一级片 |