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首頁(yè) > 抗體 > 一抗 > 其它 > HDAC4 Monoclonal Antibody
HDAC4 Monoclonal Antibody
商品貨號(hào)： PLA005111
適 應(yīng) 性： 人,小鼠,大鼠
WB
￥600元
規(guī)格：
在線咨詢
MSDS
說(shuō)明書(shū)
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： HDAC4
  • 蛋白名稱： Histone deacetylase 4
  • Human_gene_id： 9759
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9759
  • Human_swiss_prot_no： P56524
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P56524/entry
  • Mouse_gene_id： 208727
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208727
  • Mouse_swiss_prot_no： Q6NZM9
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6NZM9
  • Rat_gene_id： 363287
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363287
  • Rat_swiss_prot_no： Q99P99
  • Rat_swiss_link： http://www.uniprot.org/uniprot/Q99P99
  • 特異性： HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： HDAC4; KIAA0288; Histone deacetylase 4; HD4
  • 信號(hào)通路： Protein_Acetylation
  • 功能： catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,domain:The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.,PTM:Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3.,PTM:Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.,subunit:Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with KDM5B.,tissue specificity:Ubiquitous.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). .
  • 組織表達(dá)： Ubiquitous.
  • 科研貨號(hào)： PLA005111
HDAC4 Monoclonal Antibody
Catalog No PLA005111
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： HDAC4
  • 蛋白名稱： Histone deacetylase 4
  • Human_gene_id： 9759
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9759
  • Human_swiss_prot_no： P56524
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P56524/entry
  • Mouse_gene_id： 208727
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=208727
  • Mouse_swiss_prot_no： Q6NZM9
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q6NZM9
  • Rat_gene_id： 363287
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363287
  • Rat_swiss_prot_no： Q99P99
  • Rat_swiss_link： http://www.uniprot.org/uniprot/Q99P99
  • 特異性： HDAC4 Monoclonal Antibody detects endogenous levels of HDAC4 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書(shū)： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： HDAC4; KIAA0288; Histone deacetylase 4; HD4
  • 信號(hào)通路： Protein_Acetylation
  • 功能： catalytic activity:Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.,domain:The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.,function:Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.,PTM:Phosphorylated by CaMK4 at Ser-246, Ser-467 and Ser-632. Phosphorylation at other residues is required for the interaction with 14-3-3.,PTM:Sumoylation on Lys-559 is promoted by the E3 SUMO-protein ligase RANBP2, and prevented by phosphorylation by CaMK4.,similarity:Belongs to the histone deacetylase family. Type 2 subfamily.,subcellular location:Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4. The nuclear localization probably depends on sumoylation.,subunit:Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with KDM5B.,tissue specificity:Ubiquitous.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity). .
  • 組織表達(dá)： Ubiquitous.
  • 科研貨號(hào)： PLA005111
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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