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首頁(yè) > 抗體 > 一抗 > 其它 > HP1α Monoclonal Antibody
HP1α Monoclonal Antibody
商品貨號(hào)： PLA005115
適 應(yīng) 性： 人,小鼠,大鼠,牛,狗,豬
WB IF
￥600元
規(guī)格：
在線咨詢
MSDS
說(shuō)明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： CBX5
  • 蛋白名稱： Chromobox protein homolog 5
  • Human_gene_id： 23468
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23468
  • Human_swiss_prot_no： P45973
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P45973/entry
  • Mouse_gene_id： 12419
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12419
  • Mouse_swiss_prot_no： Q61686
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61686
  • 特異性： HP1α Monoclonal Antibody detects endogenous levels of HP1α protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
  • 功能： function:Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Can interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.,PTM:Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.,similarity:Contains 2 chromo domains.,subcellular location:Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.,subunit:Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with MIS12 and C20orf127. Interacts with HP1BP3.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Chromosome . Chromosome, centromere . Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. .
  • 組織表達(dá)： Epithelium,Fetal brain cortex,Placenta,
  • 科研貨號(hào)： PLA005115
HP1α Monoclonal Antibody
Catalog No PLA005115
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： CBX5
  • 蛋白名稱： Chromobox protein homolog 5
  • Human_gene_id： 23468
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23468
  • Human_swiss_prot_no： P45973
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P45973/entry
  • Mouse_gene_id： 12419
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12419
  • Mouse_swiss_prot_no： Q61686
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/Q61686
  • 特異性： HP1α Monoclonal Antibody detects endogenous levels of HP1α protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來(lái)源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說(shuō)明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： CBX5; HP1A; Chromobox protein homolog 5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha
  • 功能： function:Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Can interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.,PTM:Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.,similarity:Contains 2 chromo domains.,subcellular location:Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.,subunit:Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at 'Lys-9'. Interacts with MIS12 and C20orf127. Interacts with HP1BP3.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Chromosome . Chromosome, centromere . Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. .
  • 組織表達(dá)： Epithelium,Fetal brain cortex,Placenta,
  • 科研貨號(hào)： PLA005115
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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