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首頁 > 抗體 > 一抗 > 其它 > NCAM-L1 Monoclonal Antibody
NCAM-L1 Monoclonal Antibody
商品貨號： PLA005126
適 應 性： 人,小鼠,大鼠,狗,兔
WB
￥600元
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： L1CAM
  • 蛋白名稱： Neural cell adhesion molecule L1
  • Human_gene_id： 3897
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3897
  • Human_swiss_prot_no： P32004
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P32004/entry
  • Mouse_swiss_prot_no： P11627
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P11627
  • Rat_gene_id： 50687
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50687
  • Rat_swiss_prot_no： Q05695
  • Rat_swiss_link： http://www.uniprot.org/uniprot/Q05695
  • 特異性： NCAM-L1 Monoclonal Antibody detects endogenous levels of NCAM-L1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： L1CAM; CAML1; MIC5; Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1; CD antigen CD171
  • 信號通路： Axon guidance;Cell adhesion molecules (CAMs);
  • 功能： disease:Defects in L1CAM are a cause of partial agenesis of the corpus callosum [MIM:304100]; a X-linked disorder.,disease:Defects in L1CAM are the cause of hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS) [MIM:307000]. Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. This is usually due to blockage of cerebrospinal fluid outflow in the brain ventricles or in the subarachnoid space at the base of the brain. In children is typically characterized by enlargement of the head, prominence of the forehead, brain atrophy, mental deterioration, and convulsions. In adults the syndrome includes incontinence, imbalance, and dementia. HSAS is characterized by mental retardation and enlarged brain ventricles.,disease:Defects in L1CAM are the cause of mental retardation-aphasia-shuffling gait-adducted thumbs syndrome (MASA) [MIM:303350]; also known as corpus callosum hypoplasia, psychomotor retardation, adducted thumbs, spastic paraparesis, and hydrocephalus or CRASH syndrome. MASA is an X-linked recessive syndrome with a highly variable clinical spectrum. Main clinical features include spasticity and hyperreflexia of lower limbs, shuffling gait, mental retardation, aphasia and adducted thumbs. The features of spasticity have been referred to as complicated spastic paraplegia type 1 (SPG1). Some patients manifest corpus callosum hypoplasia and hydrocephalus. Inter- and intrafamilial variability is very wide, such that patients with hydrocephalus, MASA, SPG1, and agenesis of corpus callosum can be present within the same family.,disease:Defects in L1CAM are the cause of spastic paraplegia X-linked type 1 (SPG1) [MIM:303350]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.,disease:Defects in L1CAM may contribute to Hirschsprung disease (HSCR) [MIM:142623]. It may do so by modifying the effects of a Hirschsprung disease-associated gene to cause intestinal aganglionosis.,function:Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.,online information:L1CAM mutation Web Page,similarity:Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.,similarity:Contains 5 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Cell membrane ; Single-pass type I membrane protein . Cell projection, growth cone . Cell projection, axon . Cell projection, dendrite. Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658). .
  • 組織表達： Epithelium,Fetal brain,Liver,Pancreas,Plasma,
  • 科研貨號： PLA005126
NCAM-L1 Monoclonal Antibody
Catalog No PLA005126
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： L1CAM
  • 蛋白名稱： Neural cell adhesion molecule L1
  • Human_gene_id： 3897
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3897
  • Human_swiss_prot_no： P32004
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P32004/entry
  • Mouse_swiss_prot_no： P11627
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P11627
  • Rat_gene_id： 50687
  • Rat_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50687
  • Rat_swiss_prot_no： Q05695
  • Rat_swiss_link： http://www.uniprot.org/uniprot/Q05695
  • 特異性： NCAM-L1 Monoclonal Antibody detects endogenous levels of NCAM-L1 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： L1CAM; CAML1; MIC5; Neural cell adhesion molecule L1; N-CAM-L1; NCAM-L1; CD antigen CD171
  • 信號通路： Axon guidance;Cell adhesion molecules (CAMs);
  • 功能： disease:Defects in L1CAM are a cause of partial agenesis of the corpus callosum [MIM:304100]; a X-linked disorder.,disease:Defects in L1CAM are the cause of hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS) [MIM:307000]. Hydrocephalus is a condition in which abnormal accumulation of cerebrospinal fluid in the brain causes increased intracranial pressure inside the skull. This is usually due to blockage of cerebrospinal fluid outflow in the brain ventricles or in the subarachnoid space at the base of the brain. In children is typically characterized by enlargement of the head, prominence of the forehead, brain atrophy, mental deterioration, and convulsions. In adults the syndrome includes incontinence, imbalance, and dementia. HSAS is characterized by mental retardation and enlarged brain ventricles.,disease:Defects in L1CAM are the cause of mental retardation-aphasia-shuffling gait-adducted thumbs syndrome (MASA) [MIM:303350]; also known as corpus callosum hypoplasia, psychomotor retardation, adducted thumbs, spastic paraparesis, and hydrocephalus or CRASH syndrome. MASA is an X-linked recessive syndrome with a highly variable clinical spectrum. Main clinical features include spasticity and hyperreflexia of lower limbs, shuffling gait, mental retardation, aphasia and adducted thumbs. The features of spasticity have been referred to as complicated spastic paraplegia type 1 (SPG1). Some patients manifest corpus callosum hypoplasia and hydrocephalus. Inter- and intrafamilial variability is very wide, such that patients with hydrocephalus, MASA, SPG1, and agenesis of corpus callosum can be present within the same family.,disease:Defects in L1CAM are the cause of spastic paraplegia X-linked type 1 (SPG1) [MIM:303350]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.,disease:Defects in L1CAM may contribute to Hirschsprung disease (HSCR) [MIM:142623]. It may do so by modifying the effects of a Hirschsprung disease-associated gene to cause intestinal aganglionosis.,function:Cell adhesion molecule with an important role in the development of the nervous system. Involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. Binds to axonin on neurons.,online information:L1CAM mutation Web Page,similarity:Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.,similarity:Contains 5 fibronectin type-III domains.,similarity:Contains 6 Ig-like C2-type (immunoglobulin-like) domains.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Cell membrane ; Single-pass type I membrane protein . Cell projection, growth cone . Cell projection, axon . Cell projection, dendrite. Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658). .
  • 組織表達： Epithelium,Fetal brain,Liver,Pancreas,Plasma,
  • 科研貨號： PLA005126
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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