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Nup98 Monoclonal Antibody
商品貨號： PLA005129
適 應(yīng) 性： 人,小鼠,狗
WB
￥600元
規(guī)格：
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MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： NUP98
  • 蛋白名稱： Nuclear pore complex protein Nup98-Nup96
  • Human_gene_id： 4928
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4928
  • Human_swiss_prot_no： P52948
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P52948/entry
  • 特異性： Nup98 Monoclonal Antibody detects endogenous levels of Nup98 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： NUP98; ADAR2; Nuclear pore complex protein Nup98-Nup96
  • 功能： disease:A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.,disease:A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23.,disease:A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1.,disease:A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1.,disease:A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1.,domain:Contains G-L-F-G repeats.,function:Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport.,PTM:Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96.,similarity:Belongs to the nucleoporin GLFG family.,similarity:Contains 1 peptidase S59 domain.,subcellular location:Nup96 is localized to the nucleoplasmic side of the nuclear pore complex, at or near the nucleoplasmic basket.,subunit:Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Nucleus membrane ; Peripheral membrane protein; Nucleoplasmic side . Nucleus, nuclear pore complex . Nucleus, nucleoplasm . Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). .; Nucleus membrane . (Microbial infection) Remains localized to the nuclear membrane after poliovirus (PV) infection. .
  • 組織表達： Brain,Epithelium,Liver,Lung,Peripheral blood,Testis,
  • 科研貨號： PLA005129
Nup98 Monoclonal Antibody
Catalog No PLA005129
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： NUP98
  • 蛋白名稱： Nuclear pore complex protein Nup98-Nup96
  • Human_gene_id： 4928
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4928
  • Human_swiss_prot_no： P52948
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P52948/entry
  • 特異性： Nup98 Monoclonal Antibody detects endogenous levels of Nup98 protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： NUP98; ADAR2; Nuclear pore complex protein Nup98-Nup96
  • 功能： disease:A chromosomal aberration involving NUP98 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with PSIP1/LEDGF. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.,disease:A chromosomal aberration involving NUP98 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with HOXA9. Translocation t(11;17)(p15;p13) with PHF23.,disease:A chromosomal aberration involving NUP98 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(3;11)(q12.2;p15.4) with LNP1.,disease:A chromosomal aberration involving NUP98 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with TOP1.,disease:A chromosomal aberration involving NUP98 is found in childhood acute myeloid leukemia. Translocation t(5;11)(q35;p15.5) with NSD1. Translocation t(8;11)(p11.2;p15) with WHSC1L1.,domain:Contains G-L-F-G repeats.,function:Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport.,PTM:Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96.,similarity:Belongs to the nucleoporin GLFG family.,similarity:Contains 1 peptidase S59 domain.,subcellular location:Nup96 is localized to the nucleoplasmic side of the nuclear pore complex, at or near the nucleoplasmic basket.,subunit:Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細胞定位： Nucleus membrane ; Peripheral membrane protein; Nucleoplasmic side . Nucleus, nuclear pore complex . Nucleus, nucleoplasm . Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). .; Nucleus membrane . (Microbial infection) Remains localized to the nuclear membrane after poliovirus (PV) infection. .
  • 組織表達： Brain,Epithelium,Liver,Lung,Peripheral blood,Testis,
  • 科研貨號： PLA005129
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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