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首頁 > 抗體 > 一抗 > 其它 > PA28γ Monoclonal Antibody
PA28γ Monoclonal Antibody
商品貨號： PLA005131
適 應(yīng) 性： 人,小鼠,狗,豬
WB IF
￥600元
規(guī)格：
在線咨詢
MSDS
說明書
商品描述
  • 發(fā)貨日期： 7
  • 基因名稱： PSME3
  • 蛋白名稱： Proteasome activator complex subunit 3
  • Human_gene_id： 10197
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10197
  • Human_swiss_prot_no： P61289
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P61289/entry
  • Mouse_gene_id： 19192
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19192
  • Mouse_swiss_prot_no： P61290
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P61290
  • 特異性： PA28γ Monoclonal Antibody detects endogenous levels of PA28γ protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PSME3; Proteasome activator complex subunit 3; 11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma
  • 信號通路： Proteasome;Antigen processing and presentation;
  • 功能： disease:Sera from patients with systemic lupus erythematosus often contain antibodies that react with the Ki antigen.,domain:The C-terminal sequences affect heptamer stability and proteasome affinity.,function:Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.,induction:Up-regulated in thyroid carcinoma cells.,PTM:Phosphorylated by MAP3K3.,similarity:Belongs to the PA28 family.,subcellular location:Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.,subunit:Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with TP53/p53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Cytoplasm . Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. .
  • 組織表達(dá)： B-cell,Embryonic kidney,Fetal brain,Human endometrium carcinoma cell line,L
  • 科研貨號： PLA005131
PA28γ Monoclonal Antibody
Catalog No PLA005131
Product information
  • 發(fā)貨日期： 7
  • 基因名稱： PSME3
  • 蛋白名稱： Proteasome activator complex subunit 3
  • Human_gene_id： 10197
  • Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10197
  • Human_swiss_prot_no： P61289
  • Human_swiss_link： http://www.uniprot.org/uniprotkb/P61289/entry
  • Mouse_gene_id： 19192
  • Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19192
  • Mouse_swiss_prot_no： P61290
  • Mouse_swiss_link： http://www.uniprot.org/uniprot/P61290
  • 特異性： PA28γ Monoclonal Antibody detects endogenous levels of PA28γ protein.
  • 組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 來源： Monoclonal, Mouse
  • 稀釋： WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
  • 純化工藝： Affinity purification
  • 濃度： 1 mg/ml
  • 儲存： -15°C to -25°C/1 year(Do not lower than -25°C)
  • 說明書： 1
  • Msds： MSDS_Antibody.pdf
  • 其他名稱： PSME3; Proteasome activator complex subunit 3; 11S regulator complex subunit gamma; REG-gamma; Activator of multicatalytic protease subunit 3; Ki nuclear autoantigen; Proteasome activator 28 subunit gamma; PA28g; PA28gamma
  • 信號通路： Proteasome;Antigen processing and presentation;
  • 功能： disease:Sera from patients with systemic lupus erythematosus often contain antibodies that react with the Ki antigen.,domain:The C-terminal sequences affect heptamer stability and proteasome affinity.,function:Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a donut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-TP53/p53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of TP53/p53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.,induction:Up-regulated in thyroid carcinoma cells.,PTM:Phosphorylated by MAP3K3.,similarity:Belongs to the PA28 family.,subcellular location:Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.,subunit:Homoheptamer; the stability of the heptamer is essential for the specific activation of the trypsine-like subunit and inhibition of the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits of the proteasome. Interacts with TP53/p53 and MDM2. Interacts with MAP3K3 (By similarity). Associates with the proteasome.,
  • 相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
  • 細(xì)胞定位： Nucleus . Cytoplasm . Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase. .
  • 組織表達(dá)： B-cell,Embryonic kidney,Fetal brain,Human endometrium carcinoma cell line,L
  • 科研貨號： PLA005131
    • Hunan UPT Biotechnology Co.,Ltd
    Website：www.jx3dscan.com Servive hotline :4006916686
    E-mail：service@uptbio.com
    Address：
    Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.
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